Most likely, this is a result of misclassification of prevalent GLP-1 RA users as incident users, which may be the case for patients who receive prescriptions from pharmacies and hospitals not included in the LRx country-specific databases and who subsequently switch to those that are included

ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population ( Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide ( Mechanisms related to cardiovascular effects of GLP-1 receptor agonists The cardiovascular effects of GLP-1 receptor agonists in CVOTs can be attributed to several mechanisms
van de Leemput J, Hess JL, Glatt SJ, Tsuang MT
If you miss a dose and there are more than 2 days (48 hours) until your next scheduled injection, take the missed dose as soon as possible
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