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In the murine model, glucose-stimulated GLP-1 release is blocked using Na-dependent GLUT-1 (SGLT-1) knockout mice and SGLT-1 inhibitors (Reference Gorboulev, Schrmann and Vallon27,Reference Kuhre, Frost and Svendsen28) , which suggests that glucose metabolism uses glucose transport via SGLT-1 to induce GLP-1 secretion
The soluble leptin receptor represents the main leptin-binding activity in human blood
doi:10.1371/journal.pone.0074381 11
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