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The clinical evidence is compelling

In case of treatment failure, either primary non-response or secondary failure to anti-TNFs, TDM may dictate the best therapeutic strategy, either by modifying the dosing scheme or switching out of anti-TNF- therapy [135, 137]

Microglial cells are additional culprits in PD scene

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They promote deterioration of skeletal quality similar to the use of exogenous steroids, which is the leading cause of secondary osteoporosis

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