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When Semaglutide May Not Be Appropriate Certain conditions make semaglutide unsuitable, including pregnancy or breastfeeding, personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, or history of pancreatitis

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RB1 is another upstream suppressor of ACSL4, whose loss can activate transcription factor E2F1 binding to the promoter of ACSL4 by increasing the transcriptional levels of E2F1 , thus promoting the occurrence of ferroptosis [139]

& Lobo, R