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As we age, the body's natural antioxidant production tends to slow down, while the cumulative exposure to oxidative stress increases
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Methylenetetrahydrofolate dehydrogenase ( MTHFD1 ) MTHFD1 is a trifunctional enzyme of pivotal importance in the interconversion of folate cofactors for either nucleic acid synthesis or hcy remethylation reactions (Figure 1)
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Especially in some obese diabetic patients, FFAs increased significantly (Ghosh et al., 2017)
This explanation is no doubt parsimonious, but difficulties arise in trying to reconcile hyperhomocysteinemia with GSH levels: Hcy is directly upstream of cysteine, therefore vitamin B 12 deficiency ought to boost GSH synthesis
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