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Microdosing and alternative dosing of GLP-1s has not been studied nor is FDA approved
1:13He is a very small figure
7,8 When the multiple risk factor group (ie, those without an established cardiovascular event) was looked at on its own and meta-analysis undertaken with a similar group from CANVAS, the combined end point of cardiovascular death and hospitalisation for heart failure showed a 16% reduction (HR = 0.84, 95% CI 0.69 to 1.01), although this did not quite achieve statistical significance (p=0.06, Figure 4)
Topol noted that "there is no evidence from randomized trials in humans that any of these peptides provide the benefits that are advocated," and the same evidence gap applies in reverse to long-horizon harms
A microdosing tirzepatide chart can help structure this approach
The Psychosocial Dimension The psychosocial implications of GLP-1 use during perimenopause are perhaps the most significantly overlooked area of study
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