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Retatrutide and newer agents Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, is still in clinical development but early data suggest similar gastrointestinal side effect profiles

Long-term safety note: Ipamorelin was well-tolerated in its Phase II clinical trial at doses up to 0.03 mg/kg IV twice daily for up to 7 days (Beck et al., 2014)

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