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In a research on the mechanism of carp liver inflammation, dietary Se deficiency can lead to Se deficiency in blood and liver, leading to overexpression of heat shock protein HSP60 in the liver, aggravating and forming inflammatory damage to the liver (Gao et al., 2019)

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In rodent models, intracerebroventricular (icv) administration of streptozotocin (STZ) has been widely used to mimic sporadic AD by inducing brain insulin resistance, oxidative stress, and cognitive decline, without affecting peripheral glycemic control

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