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Its a complete disaster for any serious researcher

Sobos articles on GLP-1 weight loss plateaus, GLP-1 muscle loss, food noise, and what happens after GLP-1 weight loss all connect to the same principle: medical weight loss is not only about access to medication

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

I have been seeing Joe since December 23rd

Pharmacol Ther 71, 15391

This simplified the trial design but raises legitimate questions about whether weight-based dosing might improve outcomes