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What can make diarrhea worse while taking GLP-1 drugs
From a pathophysiology standpoint, this is not entirely surprising
The STEP trials and real-world data show sustained safety and efficacy over extended periods
Standard practice includes: Baseline thyroid function tests (TSH and free T4) before initiating GLP-1 therapy Repeat testing at 812 weeks after starting treatment or after dose escalation Regular monitoring every 36 months during active weight loss Return to annual monitoring once weight is stable and thyroid function remains consistent Adjustments to levothyroxine dosing may be necessary as weight changes
Methods Study participants, biosampling and proteomics profiling A total of 3,171 men and women were randomized into the STEP 1 (NCT03548935
5H) and reserve capacity (Fig
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