High-fat meals dramatically worsen nausea on GLP-1 agonists because gastric emptying is already slowed by the drug
The oral GLP-1 space is getting crowded, but orforglipron currently leads the pack in terms of clinical data and regulatory progress
Monitor blood ketones weekly if optimization is a priority
In this context, GLP-1mediated improvements in brain insulin sensitivity address a foundational energetic deficit rather than a downstream consequence of neurodegeneration [15]
R., Tyrberg, B., Hussain, T
We used DMRS and FDG-PET to record the metabolic dynamics, and rs-fMRI to record the functional activity, from the brains of GLP-1R KO and WT mice