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Its one of those trace nutrients that doesnt need much to make a big difference, and once you understand how it works, you might wonder why it hasnt been on your radar all along
For example, mTOR signaling must be modulated to promote autophagy and clearance of toxic protein aggregates (e.g., A or tau) without compromising synaptic maintenance [280]
Figure 6
It plays an important role in supporting the effectiveness of glutathione in the body
The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin
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