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In contrast, the effects of glucose on GLP-1 secretion, depending on co-transport with Na + via sodium-glucose transporter 1 (SGLT1), is strongly inhibited by this maneuver [20]

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This framework highlights that GLP-1RAs exert metabolic benefits extending beyond glucose regulation, acting as a mechanistic bridge between gut microbial dynamics and the integrated control of AT function and whole-body energy homeostasis [146,147]

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