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7 Discussion Current MASLD management primarily relies on lifestyle interventions, including weight reduction, dietary modification, and physical activity ( This review has systematically summarized evidence suggesting that L-carnitine exerts multi-targeted actions against MASLD pathogenesis by promoting lipid metabolism, improving insulin sensitivity, stabilizing hepatocyte function, and inhibiting inflammatory and fibrotic signaling pathways

Crystal structure of maleylacetoacetate isomerase/glutathione transferase Zeta reveals the molecular basis for its remarkable catalytic promiscuity

The main scientific questions include: How does triple receptor engagement differ from single-receptor or dual-receptor models

3 Composition of gut bacteria and the GBA The composition of gut microbial communities varies among individuals, and approximately 70% of species-level phylogenetic types are distinct to each person (60)

Blunted vagal cocaine- and amphetamine-regulated transcript promotes hyperphagia and weight gain

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