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It circulates at relatively high concentrations when you're young, around 200 ng/mL in your 20s , and drops steadily with age, reaching roughly 80 ng/mL by your 60s

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What makes the story even more complicated is that GH has concentration-dependent effects on tissues, as there are indications that one needs less GH to stimulate gluconeogenesis and glycolysis versus IGF-1 generation [34,38]

10.1161/01.res.0000040397.23817.e5 261 SawabeK.YamamotoK.HaradaY.OhashiA.SugawaraY.MatsuokaH.et al (2008)