The underlying mechanisms of NDD, including T21, are not yet fully understood 1
Funding This research was supported by the China Postdoctoral Science Foundation (2021M701420), Guangdong Basic and Applied Basic Research Foundation (2022A1515110021), Guangzhou Science and Technology Projects Foundation (202201020002), Scientific Research Project of Guangdong TCM Bureau (20221105), Guangdong Medical Research Foundation (A2022214)
While more research is needed, the picture is promising
If body composition is your main concern: A Midi clinician can walk you through options ranging from GLP-1 medications (like semaglutide or tirzepatide) to other approaches like metformin, Contrave, or supplements like berberine, alongside personalized lifestyle strategies
Arginine induces IGF-1 secretion from the endoplasmic reticulum
Supplementing with L-carnitine has been shown to increase peak power, improve endurance, and lower perceived exertion during high-intensity exercises (Mielgo-Ayuso et al., 2021)