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Kumbhani, MD, SM, FACC Barbara Wiggins, PharmD, FACC Megan Coylewright, MD, MPH, FACC, Ex Officio Table of Contents Preface 537 1

This synthetic peptide mimics EPOs tissue-protective properties by specifically binding to the innate repair receptor (IRR), a distinct receptor complex that mediates cytoprotective and anti-inflammatory effects

Food cravings may return for the first time in months

Consult with your physician to confirm you meet the criteria for GLP-1 therapy

Despite the promise of the GLP-1 friendly label, its lack of regulatory definition poses challenges

Genetic insights may help provide context for optimizing both medication efficacy and muscle-preservation strategies during therapy