These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig
Insulin signaling in the brain primarily involves the PI3K/Akt/GSK3 signaling pathway, which is essential for neuronal survival, synaptic function and mitochondrial integrity
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