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175 Piperine, the active alkaloid in Piper nigrum , has been shown to not only exert anti-inflammatory and antioxidant effects but also positively influence microbiota composition

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The brain, compared with other organs, is particularly prone to lipid peroxidation due to the abundance of unsaturated fats and redox-active transition metals

MacLean A et al

Possible issues may include mild irritation, itching, dryness, or sensitivity, especially if the formula also contains alcohol, fragrance, exfoliating acids, or other strong actives