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In the context of SUD, such mechanisms could plausibly reduce craving and compulsive drug-seeking, aligning with preclinical work showing attenuation of substance-related reinforcement and with emerging clinical data suggesting reduced alcohol-related outcomes among GLP-1RA users (18, 35)

Food and Drug Administration (FDA) for medical or human use

(2026, June 15)

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For weight management specifically, lifestyle modification remains foundational, incorporating medical nutrition therapy, structured physical activity programs, and behavioral counseling