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Conclusiones y relevancia: Este estudio de emulacin de un ensayo clnico objetivo en adultos con diabetes tipo 2 hall que el inicio de un agonista del receptor de GLP-1 se asoci con un menor riesgo de fractura por fragilidad a los 3 aos en comparacin con el inicio de un inhibidor de la DPP-4, independientemente de los cambios en el ndice de masa corporal y la hemoglobina glicosilada (HbA1c)
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These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7
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The endocrine system produces molecules that are used to carry messages to various parts of the body
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