Their active center is a conserved tetramer composed of selenocysteine residues (Sec), glutamine (Gln), tryptophan and asparagine
Dai X, Yue Z, Eccleston ME, Swartling J, Slater NKH, Kaminski CF
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Notably, GLS-mediated deamination of glutamine to glutamate is the first and rate-limiting step of glutaminolysis, making it an attractive druggable target 9
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The most common symptoms, which are mild and temporary, include abdominal pain, loose stools, and increased flatulence (mostly associated with oral supplementation)