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The new biology and pharmacology of glucagon
Ranganath ( In the central nervous system, proglucagon and proglucagon-derived peptides (GLP-1, glucagon-like peptide-2, GLP-2, and oxyntomodulin, OXM) are only present in a small group of neurons in the nucleus tractus solitarius ( In addition, the GLP-1 can inhibit postprandial gastric emptying and reduce gastric acid secretion, inhibit gastric and duodenal peristalsis by inhibiting vagus nerve, and increase the pressure of pylorus, thus reducing appetite, causing a reduction in body weight and participating in the so-called ileal braking effect (39)
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Sattar N, Lee MMY, Kristensen SL, Branch KRH, Del Prato S, Khurmi NS, Lam CSP, Lopes RD, McMurray JJV, Pratley RE, et al
Sci Rep (2019) 9:12986
A 15% body weight reduction the STEP-1 semaglutide benchmark is associated with type 2 diabetes remission in 37% of treated patients, 28% reduction in hypertension medication requirements, 25% improvement in sleep apnea severity, and MASH progression reversal
