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Assessment of pancreas safety in the development program of once-weekly GLP-1 receptor agonist dulaglutide

If a patient takes a drug that is available in a non-oral formulation (e.g., transdermal estradiol instead of oral estradiol, patch-based hormone therapy instead of oral HRT), switching reduces the interaction risk without requiring drug-level monitoring

NICE guidelines (NG28) recommend blood pressure targets below 140/80 mmHg (or 130/80 mmHg if kidney, eye, or cerebrovascular damage is present) and lipid management according to cardiovascular risk

M., & Dehghan, P

Other Common Side Effects Beyond digestive issues, some people experience: Injection site reactions: Redness, swelling, or irritation where you inject the medication Fatigue: Feeling more tired than usual, especially when starting treatment Headaches: Usually mild and temporary Dizziness: May occur, particularly when blood sugar levels improve Serious but Rare Side Effects While GLP-1 medications are generally safe, some serious side effects can occur

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