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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771

The protocols in use come from extrapolation of animal data, pharmacokinetic studies, and clinical experience from practitioners who have incorporated the compound into their practice

B12 shots can be especially helpful if you are older, do not eat animal products, have conditions that impact nutrient absorption, or take medications that interfere with nutrient absorption

The mechanism of action is well-characterized and makes biological sense

It remains a research compound that some clinics and individuals have begun using despite the lack of regulatory approval

By inhibiting this enzyme, NAD+ levels rise within cells, leading to enhanced energy metabolism , lipid breakdown , and mitochondrial activation