These effects often diminish as your body adjusts to the medication
Cardiology 2010;115(1):71-74
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Tyrosinase undergoes catalytic reactions through three oxidative states: oxidized tyrosinase (oxy), met tyrosinase (met), and deoxy tyrosinase (deoxy) 1,16
Patients who should proactively discuss this finding with their prescribing physician include: Postmenopausal women initiating or currently using GLP-1 drugs for weight loss without diabetes Adults 65 and older taking any GLP-1 medication Patients with a prior fragility fracture or documented osteoporosis Patients with low body weight or low BMI who begin GLP-1 therapy (they have less weight-based mechanical loading to begin with) People with conditions that independently affect bone density, including celiac disease, inflammatory bowel disease, prolonged corticosteroid use, or thyroid disease Symptoms and Warning Signs to Watch For Bone density loss is typically silent until a fracture occurs
Preclinical combination data exists