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One should not use AOD-9604 if they: Are pregnant or breastfeeding Are a minor Have a current or recent history of cancer (particularly hormone-sensitive cancers) Have uncontrolled diabetes or significant insulin resistance Have active thyroid disease that is not well-managed Are taking medications that may interact with peptide therapy (discuss with your provider) Have a known hypersensitivity to peptide compounds Comprehensive labs including metabolic panel, fasting glucose, HbA1c, thyroid panel, lipid panel, and hormone levels should be run before starting any peptide therapy and monitored regularly throughout

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doi: 10.1016/j.lwt.2020.109260 7 ChoiE

The key to consistent dosing is accurate preparation

do not obtain retatrutide from online pharmacies, compounding services, or any unregulated source On the day of your injection: Eat a light, low-fat meal beforehand rather than a large or greasy one, as this may worsen nausea Inject at a time of day that suits your schedule many people prefer mornings so that any early reactions can be monitored while awake Rotate injection sites to reduce localised skin reactions Remain well hydrated throughout the day Sharps safety: Dispose of used needles and syringes immediately in the sharps bin provided by your trial team Never share needles, syringes, or injection pens with anyone else Follow your local NHS arrangements for the collection or disposal of full sharps bins Ongoing safety considerations: Do not adjust your dose without medical guidance If you are taking insulin or other glucose-lowering agents, your clinician may need to review and adjust these to reduce the risk of hypoglycaemia Limit alcohol, particularly in the early weeks of treatment, as it may worsen nausea and dizziness If you experience significant vomiting or diarrhoea, discuss 'sick day rules' for any other medicines you take (for example, certain blood pressure or diabetes medications) with your clinical team Keep a written or digital log of any symptoms to share with your healthcare team at your next appointment In line with NICE guidance on shared decision-making, your healthcare team should have discussed the potential benefits, risks, and alternatives with you before commencing treatment