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In 2015, triple agonists simultaneously targeting the GLP-1R, GCGR, and GIPR were also developed, whose weight loss in mice exceeded those of the dual agonists [26]

Even a modest weight loss of 5% has been shown to improve cardiometabolic risk factors, including reduced systolic blood pressure and plasma triglyceride concentration, and increased multi-organ insulin sensitivity and -cell function [6]

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Brand-name medications such as Ozempic and Wegovy may be prescribed when clinically appropriate

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