In the research community, sustained or supraphysiologic IGF-1 exposure is associated with progressive abdominal distension (sometimes called 'GH gut') and concern for cardiac hypertrophy
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This is a condition wherein brown or black pigmentation develops inside the mouth and throat
some references extend to ~12 weeks
Oxidative stress leads to lipid peroxidation, which generates a variety of oxidative compounds, including hexanal, 4-hydroxy nonanal (4-HNE), and malondialdehyde (MDA)
Similarly, after losing 80 pounds on a paleo diet, the weight all came back once I could no longer avoid the lure of grains and sugar