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The observed gender differences in nicotine craving reductions indicate that female participants were significantly more likely to report reduced nicotine cravings compared with males, a finding that remained significant after adjustment for potential confounders (adjusted odds ratio [aOR] 0.27 for males vs females, 95% CI 0.120.61

The first suggests that OPZ acts through a bioactive metabolite following reaction with cellular thiols

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This method allows your body to utilize nearly 100% of the antioxidants, bypassing the digestive system entirely

10.1186/s13098-025-01623-w 55 MuayadJ.LoyaA.HussainZ