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We were quite excited by the findings, as this study was the first to demonstrate a physiological role of GLP-1 in appetite control and energy intake in humans

By tagging the substrates with ubiquitin, E3 ligases provide a platform for protein-protein interactions that can modulate the activity, localization or interaction of the target proteins, thereby triggering different biological signals to regulate a variety of cellular processes including cell cycle, cell division, stress response, DNA repair and apoptosis etc 1,2,3,4

Kawata T, Kanamori A, Kubota A, Maeda H, Amamiya H, Takai M, Kaneshige H, Minagawa F, Iemitsu K, Kaneshiro M, Ishikawa M, Takeda H, Takuma T, Mokubo A, Machimura H, Obana M, Miyakawa M, Naka Y, Suzuki D, Terauchi Y, Toyoda M, Tanaka Y, Matsuba I

Mielgo-Ayuso, J., Marques-Jimnez, D., Refoyo, I., Del Coso, J., Len-Guereo, P., & Calleja-Gonzlez, J

New York, NY: Springer New York