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Additional funding was received by the STAEDTLER foundation, the Johannes und Frieda Marohn-Stiftung, the Else Krner-Fresenius Foundation, the Interdisciplinary Centre for Clinical Research, Erlangen (IZKF) and the Bundesministerium fr Bildung und Forschung (BMBF) BMBF-MASCARA TP No.4, the TEAM project of the European Union and the IMI-funded project EU IMI2-RTCure