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Its diversity and vulnerability make the involved pathway proteins potential therapeutic targets (Valdecantos et al., 2024)

CrossRef Circadian rhythms of gut microbiota modulate nocturnal hyperglycemia in type 2 diabetes: a comprehensive review on mechanisms and chrono-targeted interventions Hanchi Ying, Qi Wang, Qian He, Yibo Cao, Guangyao Wei, Zhiqiang Xiao, Xiaoting Luo Frontiers in Microbiology.2026;[Epub] CrossRef Targeting the GLP-1 receptor pathways for dual management of obesity and depression Ruchi Keswani, Shvetank Bhatt Drug Discovery Today.2026

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Currently, Saxenda (Liraglutide - NVO) and Wegovy (Semaglutide - NVO) are the two GLP-1 drugs approved for weight loss by the FDA

Angiotensin-converting enzyme inhibitors (ACEIs) are widely used as anti-hypertensives and for treatment of diabetic nephropathy