It has also been associated with psychogeriatric dis-ease, depression, high neurotoxin activity, and a decrease in intellectual function such as episodic and visuospatial memory, attention, and abstract reasoning (20).Reynolds and colleagues found that 17 out of 24 hospitalized patients (71%) presenting severe folic acid deficiency were diagnosed with depression (46)
Broad Institute Connectivity Map analysis shows it influences approximately 6% of the human genome making this one of the most broadly active signaling peptides in published research
Together, these results support the hypothesis that cysteine derived from lysosomal cystine efflux limits the activity of the -glutamyl cycle and GSH synthesis
John David Henneberry-Fudge, MD, FRCPC
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Exp Pathol 28, 139