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Starting at the lowest dose and increasing slowly over months, rather than rushing to the target dose, dramatically reduces gastrointestinal side effects and improves long-term tolerability

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-Ketoglutarate (-KG), a TCA cycle intermediate, serves as an essential cofactor for TET and JmjC demethylases, facilitating DNA and histone demethylation [251]

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Mean glycated hemoglobin was 5.8%, with two-thirds of patients meeting criteria for prediabetes (5.7% to 6.4%)