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Defects in the FAH gene result in the accumulation of the upstream tyrosine metabolites, maleylacetoacetate and fumarylacetoacetate, as well as their metabolic by-products succinylacetone and succinylacetoacetate
The principle of using the minimum effective intervention applies, particularly given the lack of clinical trial data supporting combination therapy and SmPC cautions against coadministration with other weight-loss medicines