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It is hypothesized that this results in a glutamate surge, ultimately agonizing postsynaptic AMPA-glutamate receptors and triggering production of brain-derived neurotrophic factor, which orchestrates synaptogenesis and neuroplasticity ( This cascade of events is believed to be responsible for the observed increase in global brain connectivity in the prefrontal cortex of individuals with MDD within 24 hours of a single ketamine infusion and imaged with functional connectivity MRI

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