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GIP stands for glucosedependent insulinotropic polypeptide (also called gastric inhibitory polypeptide)

Neuroinflammation and neurotoxic KP metabolites like QUIN suppress neurogenesis in the adult hippocampus and reduce levels of Brain-Derived Neurotrophic Factor (BDNF), a molecule essential for neuronal survival, growth, and plasticity (Craig et al., 2022)

36 Similar to the findings previously noted for the PIONEER 5 study, no differences were seen in any pharmacokinetic or safety parameters based on baseline kidney function, including participants receiving hemodialysis

Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Mirzoyan K, Klavins K, Koal T, Gillet M, Marsal D, Denis C, et al