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Schulte-Herbruggen et al., 2007

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Unlike older weight loss medications, Retatrutide activates three different receptors (GLP-1, GIP, and glucagon), creating a synergistic effect that amplifies fat burning and appetite control beyond what single or dual receptor agonists achieve

How They Work in the Body As mentioned, tesofensine and semaglutide use very different mechanisms to achieve the desired effects

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