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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

To get a therapeutic amount into your cells using standard pills, you would often need to take an uncomfortably high volume of supplements, which can sometimes lead to digestive upset

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The resulting metabolite levels were then normalized to those from matched distal nontumor samples from the same patients, and logtransformed