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The slowed gastrointestinal motility induced by tirzepatide can contribute to stool retention and increased colonic transit time

GIP has been shown to decrease how much you eat and increase your energy expenditure, which results in weight loss

Both semaglutide and tirzepatide underwent randomized, placebo-controlled trials for obesity, with marked reduction of weight as shown below

Together, these medications address multiple pathophysiological mechanisms, providing superior glycaemic control and weight management compared to either treatment alone