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Atorvastatin induces mitochondria-dependent ferroptosis via the modulation of Nrf2-xCT/GPx4 axis
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It facilitates cellular communication by binding copper ions, which activates metalloproteinases and growth factors involved in collagen and elastin production, DNA repair, and cellular proliferation
Studies in rat models demonstrate that spironolactone can prevent histological and functional alterations caused by doxorubicin, including myocardial fibrosis and elevated cardiac enzymes [170]
Chiricozzi 2012
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