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Nevertheless, since GSH cannot be administered directlybecause of its insufficient absorption, stability and solubilityanalogues have been obtained, through modifications at the -glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105
However, when these therapies are administered to somatic cells in adults and only used for a short period during the perioperative period, the associated risks related to germline transmission are significantly reduced
Its large size may affect native conformation remove with specific proteases (PreScission, thrombin) after purification for structural/functional studies
It is not for human consumption, animal consumption, veterinary use, diagnostic use, cosmetic use, therapeutic applications, or medical treatment
10.1038/tp.2012.61 22
As the oral route is not very good for glutathione absorption to replenish lost supplies, there are other ways to do so
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