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Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy

This keeps the work aligned with regulatory guidance while still allowing for detailed exploration of how the peptide behaves in various models

Additionally, histological assessment involved Tyrosine Hydroxylase (TH) staining in the substantia nigra to evaluate the integrity and potential restoration of dopaminergic neurons, with evaluations performed at 1 month and 3 months post-lesion

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Hydroxocobalamin is classified as Pregnancy Category C in the United States, indicating that risk to the fetus cannot be ruled out in the absence of definitive human data

Discard the vial when its expiration or recommended in-use period is reached