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Mol Cancer Ther 5:3951 McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ (2007) Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition

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Cognitive & Circadian Restoration It has shown potential to reduce neuroinflammatory cytokines (e.g., TNF-, IL-6) and stabilize circadian gene oscillations, which may benefit sleep, mood, and cognitive clarity

The most-cited theoretical concern is angiogenesis: both compounds promote new blood vessel formation, which is the intended repair mechanism but also a pathway relevant to tumor growth

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