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NHS and Manufacturer Recommendations: Use a barrier method (like condoms) for at least 4 weeks after starting Mounjaro Also apply the 4-week barrier rule after each dose increase Consider switching to non-oral forms of contraception (e.g., patch, IUD, implant) 2

Acknowledgements The authors thank the research resource division (RRD) (RIKEN Center for Brain Science) and RIKEN CBS-EVIDENT Open Collaboration Center (RIKEN Center for Brain Science) for technical assistance, Yukiko Nagai (RIKEN Center for Brain Science) for secretarial work, Kenichi Nagata (Nagoya University) and members of the Laboratory for Proteolytic Neuroscience (RIKEN Center for Brain Science) for beneficial suggestions

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10.15252/embr.202357413 85 NegreiraG

For severe deficiency, the AAFP recommends loading doses typically daily or every other day for one to two weeks followed by monthly maintenance injections

Provided as lyophilized powder with characteristic blue coloration