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Several research studies with rodents fed a high-fat diet, different animal models of obesity and diabetes, and patients diagnosed with T2DM have all shown changes in gut microbiota caused by metformin, as shown in Table 1

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Ex-4 has similarly been shown to inhibit the proliferation of prostate and breast cancer cells via suppression of the same pathway [65]

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This may include GLP-1 drugs or alternatives, such as metformin or bupropion