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The existing amylin analogue pramlintide (sold as Symlin in the US for diabetes management) requires multiple daily injections

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In vitro studies have characterised its binding interactions with nitric oxide-related signalling systems and its effects on extracellular matrix protein expression in cell culture models

A brand-new 2024 pilot gave two healthy adults up to 20 mg intravenously for two days zero side effects, normal blood tests, heart, liver, kidney, and thyroid markers all fine

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When combined with amylin-like signaling from cagrilintide, the overall effect may be stronger appetite suppression than with a single pathway alone