Women taking these medications lose an average of 11% of their starting body weight
Cochrane Database Systematic Rev
The gap between the best injectable and the best pill is real, but it is narrowing, and less than the maximum is not the same as ineffective an 11% to 12% weight loss is a significant health outcome
The influence of GSTT1 present or null genotypes is shaped much more by environment, coexisting pathways, and lifestyle than by the gene alone, which means you have meaningful room to change the trajectory
In both animal studies and some early human research, activation of this pathway has been associated with reduced food intake and, in some cases, modest weight loss
distribution, release and actions