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Overall, telomerase plays an essential role in fertilization and organ development by regulating cellular processes such as signaling pathways and apoptosis [64, 65] and its dysregulation can result in aging, as well as several human disorders such as dyskeratosis congenita [66] and idiopathic pulmonary fibrosis (IPF) [67]
To induce intracellular GSH depletion, cells were incubated in Cys 2 -free medium or with BSO (1000 M) treatment or erastin (10 M) treatment
Brenner DM, Shin AS, Laitman AP, Deutsch JK, Kunkel DC
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